Computerized system for methodological test analysis for hospital
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ABSTRACT
In hospitals, test analysis is conducted to find out the disease that is affecting the patients. For sickle cell disease, it is a genetic disease and needs a methodological test analysis.
This study is carried out to design and implement a computerized system for the methodological test analysis as a tool to revolutionize medical profession. It was principally a case study of sickle cell disease. This will help to reduce the problems inherent in our hospitals today with regard to conducting medical test and obtaining accurate test result.
The programming language employed in the implementation of this research work is visual Basic 6.0.
CHAPTER ONE
INTRODUCTION
1.1 Background of the Study
This collection of clinical findings was unknown until the explanation of the sickle cells in 1910 by the Chicago cardiologist and professor of medicine James B. Herrick (1861–1954), whose intern Ernest Edward Irons (1877–1959) found “peculiar elongated and sickle-shaped” cells in the blood of Walter Clement Noel, a 20-year-old first-year dental student from Grenada, after Noel was admitted to the Chicago Presbyterian Hospital in December 1904 suffering from anaemia.
Noel was readmitted several times over the next three years for “muscular rheumatism” and “bilious attacks”. Noel completed his studies and returned to the capital of Grenada (St. George’s) to practice dentistry. He died of pneumonia in 1916 and is buried in the Catholic cemetery at Sauteurs in the north of Grenada. Herrick’s published account included illustrations, but the earliest available slide showing sickle cells is that of a 1918 autopsy from a soldier with sickle trait, initially reviewed only 92 years later.
The disease was named “sickle-cell anemia” by Verne Mason in 1922, then a medical resident at Johns Hopkins Hospital. However, some elements of the disease had been recognized earlier: A paper in the Southern Journal of Medical Pharmacology in 1846 described the absence of a spleen in the autopsy of a runaway slave. The African medical literature reported this condition in the 1870s, when it was known locally as ogbanjes (“children who come and go”) because of the very high infant mortality rate caused by this condition. A history of the condition tracked reports back to 1670 in one Ghanaian family. Also, the practice of using tar soap to cover blemishes caused by sickle-cell sores was prevalent in the black community.
Linus Pauling and colleagues were the first, in 1949, to demonstrate that sickle-cell disease occurs as a result of an abnormality in the haemoglobin molecule. This was the first time a genetic disease was linked to a mutation of a specific protein, a milestone in the history of molecular biology, and it was published in their paper “Sickle Cell Anemia, a Molecular Disease”.
1.2 Statement of the Problem
Sickle-cell conditions are inherited from parents in much the same way as blood type, hair color and texture, eye colour, and other physical traits. The types of haemoglobin a person makes in the red blood cells depend on what haemoglobin genes are inherited from his parents. If one parent has sickle-cell anaemia (SS) and the other has sickle-cell trait then there is a 50% chance of a child’s having sickle-cell disease and a 50% chance of a child’s having sickle-cell trait. When both parents have sickle-cell trait a child has a 25% chance of sickle-cell disease. So, there is need to prevent both partners having sickel cell from getting married as this will result in bearing children with sickle cell trait. Therefore, there is need to develop a methodological test analysis to determine the possibility of parents having children with sickle cell trait.
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